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Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.

Identifieur interne : 003A39 ( Main/Exploration ); précédent : 003A38; suivant : 003A40

Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.

Auteurs : R C Bucknall ; J. Dixon A St ; E N Glick ; J. Woodland ; D W Zutshi

Source :

RBID : ISTEX:F9CA784AEC1A748A5F8F69D437019618414B5224

English descriptors

Abstract

Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.

Url:
DOI: 10.1136/bmj.1.5958.600


Affiliations:


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Le document en format XML

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<term>Edrophonium chloride</term>
<term>Gravis</term>
<term>Helpful information</term>
<term>Intercellular region</term>
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<div type="abstract" xml:lang="en">Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.</div>
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