Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.
Identifieur interne : 003A39 ( Main/Exploration ); précédent : 003A38; suivant : 003A40Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.
Auteurs : R C Bucknall ; J. Dixon A St ; E N Glick ; J. Woodland ; D W ZutshiSource :
- British Medical Journal [ 0007-1447 ] ; 1975-03-15.
English descriptors
- Teeft :
- Antinuclear factor, Cardiac output, Chest radiography, Consultant neurologist, Edrophonium chloride, Gravis, Helpful information, Intercellular region, International symposium, Latex test, Multicentre trial group, Myasthenia, Myasthenia gravis, Oxygen binding curve, Oxygen transport, Penicillamine, Penicillamine treatment, Present appointment, Pyridostigmine, Rheumatic diseases, Rheumatoid, Rheumatoid arthritis, Rheumatoid factor, Royal infirmary, Royal society, Schirmer test, Senior registrar, Sodium aurothiomalate, Spontaneous remission, Systemic lupus erythematosus, Thoracic inlet tomogram, Thyroid function, Tissue damage, York academy.
Abstract
Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.
Url:
DOI: 10.1136/bmj.1.5958.600
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001736
- to stream Istex, to step Curation: 001736
- to stream Istex, to step Checkpoint: 002786
- to stream Main, to step Merge: 003B19
- to stream Main, to step Curation: 003A39
Le document en format XML
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<term>Edrophonium chloride</term>
<term>Gravis</term>
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<term>International symposium</term>
<term>Latex test</term>
<term>Multicentre trial group</term>
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<term>Myasthenia gravis</term>
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<term>Oxygen transport</term>
<term>Penicillamine</term>
<term>Penicillamine treatment</term>
<term>Present appointment</term>
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<term>Royal society</term>
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<term>Spontaneous remission</term>
<term>Systemic lupus erythematosus</term>
<term>Thoracic inlet tomogram</term>
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<front><div type="abstract" xml:lang="en">Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.</div>
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<name sortKey="Dixon A St, J" sort="Dixon A St, J" uniqKey="Dixon A St J" first="J" last="Dixon A St">J. Dixon A St</name>
<name sortKey="Glick, E N" sort="Glick, E N" uniqKey="Glick E" first="E N" last="Glick">E N Glick</name>
<name sortKey="Woodland, J" sort="Woodland, J" uniqKey="Woodland J" first="J" last="Woodland">J. Woodland</name>
<name sortKey="Zutshi, D W" sort="Zutshi, D W" uniqKey="Zutshi D" first="D W" last="Zutshi">D W Zutshi</name>
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